Division of Morphological Sciences & Biostatistics

Research Grant Applications Currently Under Review

Improving Outcomes for Dental Implants in Young Adults

PD/PI: Sherwood, R.J.
Co-I: Hudson, J. Nahhas, R.W.
Funding Agency: NIH/NIDCR (R21DE024842)
Dates: 12/01/2014 – 11/30/2016

The proposed proof-of-concept R21 project will (a) Accurately estimate the measurement error associated with facial measurements taken via 3dMD, as well as less expensive, digital photographic systems, (b) Determine the amount of agreement between these methods, and (c) Use simulation to generate a working hypothesis for a clinical guideline for the decision to proceed with an osseointegrated dental implant.


Craniofacial Growth Prediction in Different Facial Types

PD/PI: Nahhas, R.W., Oh, HS (Multiple PI)
Co-I: Sherwood, R.J.
Funding Agency: NIH/NIDCR (R01DE024732
Dates: 12/01/2014 – 11/30/2019

We will identify landmarks on over 25,000 lateral cephalographs from 5,247 individuals (3,340 with serial data) age 0-27 years from the nine growth studies comprising the American Association of Orthodontists Foundation Legacy Collection. Through the analysis of these data, the proposed research will 1) estimate population- and individual-level timing of pubertal growth and adult size for multiple craniofacial traits, 2) provide diagnostic reference charts for craniofacial lengths, angles, and ratios given sex, age, facial type, and cervical vertebral maturity, 3) develop prognostic tools to predict remaining growth/change and the timing of the pubertal growth spurt for craniofacial traits, 4) make these valuable resources available to clinicians and researchers via an easy-to-use free web-based application, and 5) apply geometric morphometric techniques to extend current clinical views of quantifying craniofacial growth. The overall impact of the proposed research will be a shift in the clinical management of pediatric craniofacial patients toward more evidence-based treatment planning, utilizing references and predictions based on data from the largest North American cephalometric collections.


Aging-Related Gait Trajectories in Healthy and Osteoarthritic Older Adults

PD/PI: Andrew Froehle
Co-Is: Dana Duren, Ramzi Nahhas
NIH/NIAMS (R03AR064556)
Dates: 7/1/2014 – 6/30/2017

Knee osteoarthritis (KOA) affects walking gait, is a key factor in mobility loss, and is a leading cause of general disability among older adults. The proposed research addresses this significant public health issue by developing longitudinal indices for KOA-specific patterns of decline in mobility with advancing age. This research will provide a significantly improved prognostic tool that aids physicians in planning treatment, and promotes the patient’s capacity to minimize and anticipate KOA-related disability.


Linking Menopause and Low Estrogen to Fatigability via Impaired Fat Metabolism

PD/PI: Andrew Froehle
Co-Is: Dana Duren, Ramzi Nahhas, Lynn Hartzler, Wayne Campbell (Purdue)
NIH/NIA (R21AG049316)
Dates: 12/01/2014 – 11/30/2016

Increased fatigability reduces the ability to perform activities of daily living, limiting independence and posing a substantial challenge to successful aging. The proposed research addresses a significant public health issue by determining the effects of menopausal changes in energy metabolism on aging-related increases in fatigability. This study will identify important metabolic risk factors for increased fatigability related to menopause, and will define the menopausal transition as a key window during which to prevent and treat metabolic causes of fatigability.