Division of Morphological Sciences & Biostatistics

Active Funded Research Support

Updating Skeletal Maturity Methods for U.S. Children

PD/PI: Duren, D.L.
Co-I: Sherwood, R.J., Nahhas, R.W.
Funding Agency: NIH/NIAMS, NICHD (R01AR055927)
Dates: 07/01/2014 – 06/30/2019

This study will provide up ­to­ date race­ specific modules to the FELS method for skeletal maturity assessment. This goal will be accomplished through the following three aims: (1) Determine differences between races in both the timing and tempo of skeletal maturity and its individual components. (2) Re­calibrate the FELS method using data from contemporary children and provide new, user ­friendly, free, and open source stand­alone and web ­based computer programs with sex­ and race-specific modules. (3) Integrate two new “personalized medicine” outputs into the FELS program: maturation ­category specific bone age, and conditional percentiles of skeletal age that can be used to predict the probability of “catch­up maturation” for a given child.

Longitudinal Modeling of Craniofacial Growth Trajectories

PD/PI: Nahhas RW
Co-I: Sherwood RJ
Funding Agency: NIH NIDCR
Dates: 04/01/2011–03/31/2014

The goal of the proposed research project is to precisely characterize ontogenetic trajectories across the functional/developmental components of the craniofacial complex throughout childhood and into young adulthood. This project will result in a web-based application, useful for both clinicians and basic researchers, which will provide sex- and age-specific benchmarks for the normative range of craniofacial growth and development.

Genetic Architecture of the Human Dentognathic Complex

PD/PI: Sherwood RJ
Co-Is: Duren DL, Towne B
Funding Agency: NIH/NIDCR (R01DE018497)
Dates for Award: 05/18/2009–03/31/2014

The ultimate objective of this project is to elucidate fundamental aspects of the genetic architecture of the human dentognathic complex. Quantitative data from the dentition, mandible, and maxilla will be collected from the Jirel population of eastern Nepal. Heritability of each trait will be estimated, and genetic and environmental correlations matrices will be examined for all traits. Additionally this project will seek to identify chromosomal regions (quantitative trait loci; QTL) harboring genes that influence variation in dentognathic measures.

Opioid Use Trajectories and HIV Risk Among Young Adults in Ohio
PD/PI: Carlson RG, Falck RS
Co-Is: Daniulaityte R, Nahhas RW
Funding Agency: NIH/NIDA (R01DA023577)
Dates of Award: 04/01/2008–12/31/2014

The goal of this proposed study is to describe trajectories of non-prescribed pharmaceutical opioid use and identify the factors associated with the development of DSM-IV abuse or dependence on pharmaceutical opioids (and transition to heroin use) among people aged 18-23 years old.

Post Baccalaureate Research Education (PREP)
PD/PI: Czerwinski SA
Mentor: Duren D
Funding Agency: NIH/NIGMS
Dates: 03/01/2010–02/28/2015

Supports the research training and education of recent baccalaureate graduates from groups underrepresented in biomedical and behavioral research areas, who plan to pursue Ph.D. degrees. This research apprenticeship serves as an educational transition for recent baccalaureate graduates who will acquire essential academic credentials and research skills to make them more competitive for Ph.D. programs at highly selective institutions.

Adiposity, Disease Risk Factors, and Lifetime Health
PD/PI: Czerwinski SA
Co-Is: Choh AC, Duren DL, Lee M, Nahhas RW, Towne B
Funding Agency: NIH/NICHD R01HD012252

This project involves the collection and analysis of long-term serial data from the Fels Longitudinal Study. Data are related to indices and measures of body fatness, adipose tissue distribution, lifestyle, lipids and lipoproteins, blood pressure, and other risk factors for cardiovascular disease. Analyses concern prediction of future states, associations among measures of body composition and other risk factors for cardiovascular disease, and patterns of change in individuals.