Division of Epidemiology Active Funded Research Support

Adiposity, Disease Risk Factors, and Lifetime Health
PD/PI: Czerwinski SA
Co-Is: Choh AC, Chumlea WC, Duren DL, Lee M, Nahhas RW, Towne B
Funding Agency: NIH/NICHD R01HD012252

This project involves the collection and analysis of long-term serial data from the Fels Longitudinal Study. Data are related to indices and measures of body fatness, adipose tissue distribution, lifestyle, lipids and lipoproteins, blood pressure, and other risk factors for cardiovascular disease. Analyses concern prediction of future states, associations among measures of body composition and other risk factors for cardiovascular disease, and patterns of change in individuals.

Adiposity and Ectopic Fat Depots in Relation to Cardiometabolic Risk in Pubertal Children
PD/PI: Lee M
Co-I's: Czerwinski SA, Ebert J
Funding Agency: Wright State University
Dates: 07/01/2010–12/31/2013

This study will investigate how and to what extent abdominal adiposity and liver fat is associated with health outcomes, specifically in cardiometabolic risk in overweight or obese children attending the Lipid Clinic, Children’s Medical Center of Dayton

Feasibility study for cerebrovascular health assessment
PD/PI: Choh A
Co-I's: Czerwinski SA
Funding Agency: Wright State University
Dates: 01/01/2011–12/31/2013

Brain aging is marked by cognitive decline, brain atrophy and increased prevalence of indicators of subclinical stroke such as white matter ischemic disease and cerebral microbleeds. This proposal seeks to develop research tools for use in an epidemiologic study of brain health in a sample of adults over the age of 50.  Specifically, we will refine and develop data collection and magnetic resonance (MR) image analysis protocols to quantify and analyze brain structures including regional brain volumes, white matter hyperintensities, cerebral microbleeds and stroke.

Genetics of Bone Structure and Metabolism
PD/PI: Mahaney M
Co-Is: Towne B, Czerwinski SA
Funding Agency: NIH (R01AR055632)
Subcontract from Southwest Foundation for Biomedical Research

The proposed study investigates the genetic determinants of bone metabolism and osteoporosis risk in a sample of adult participants from Jiri, Nepal. Study participants will be assessed for a variety of bone traits including bone mineral density, bone structure and markers of bone turnover. This information coupled with genetic marker data will be used to determine areas of the genome that harbor genes related to osteoporosis risk in this population.

Health Outcomes of Weight Loss

PD/PI: Lee M
Co-I's: Czerwinski SA, Corill L
Funding Agency: Wright State University
Dates: 07/01/2012–09/30/2013

This pilot study will collect data on changes in global protein profiling in a sample of non-Hispanic white and black obese women, ages 40 to 60 years, who are participating in a local weight loss intervention program.  Body composition, blood samples and lifestyle risk factor data are collected in order to quantify protein profiling in plasma due to weight loss intervention and also to investigate unique changes in protein expression profiles from longitudinal plasma samples.

Initiative for Maximizing Student Development BIOSTAR
PD/PI: Solentic
Mentor: Chumlea CW, Czerwinski SA, Lee M
Funding Agency: NIH/NIGMS
Dates: 12/01/2010–11/30/2015

The goal of the IMSD Program is to increase the number of students from groups underrepresented in the biomedical and behavioral sciences that complete the Ph.D. degree in these fields at institutions with research intensive environments.

Job Demands as Moderators of the Relationship between Physical Activity and Health
PD/PI: Choh A
Co-I's: Bowling, Czerwinski SA
Funding Agency: Wright State University
Dates: 07/01/2013–6/30/2014

This grant will extract objective measures spanning various dimensions of job demands, and examine how job-related dimensions, PA, and interactions between the two, influence obesity, blood pressure, general health, and depression, adjusting for demographic, and behavioral risk factors.

Post Baccalaureate Research Education (PREP)

PD/PI: Chumlea C
Mentor: Lee M, Czerwinski SA
Funding Agency: NIH/NIGMS
Dates: 03/01/2010–02/28/2014

Supports the research training and education of recent baccalaureate graduates from groups underrepresented in biomedical and behavioral research areas, who plan to pursue Ph.D. degrees. This research apprenticeship serves as an educational transition for recent baccalaureate graduates who will acquire essential academic credentials and research skills to make them more competitive for Ph.D. programs at highly selective institutions.

Short-term Training for Minority Students Program

PD/PI: Chumlea WC
Mentor: Lee M, Czerwinski SA
Funding Agency: NIH/NHLBI

The major goal of this project is to give short-term training in the cardiovascular sciences with emphasis on basic mechanisms of cellular and neural physiology, cardiovascular and endocrine control/epidemiology to minority undergraduates.