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CURRENTLY OPEN CLINICAL TRIALS

Dayton Clinical Oncology Program accesses clinical trials through its membership in cooperative research groups funded by the National Cancer Institute (NCI), and through the pharmaceutical industry.

For a listing of research groups and links to their web sites, go to the "Links to Other Sites" tab at the left.

Clinical Trial By Disease Site
(Click the links to advance to a specific section)

   


General Cancer Control Trials for Symptom Management

A221102

TitleStudy of Subcutaneous Testosterone in the Adjuvant Treatment of Postmenopausal Women with Aromatase Inhibitor Induced Arthralgias

N08C9

Study of Sulfasalazine versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy

S0702

Assess the Incidence of Osteonecrosis of the Jaw in Cancer Patients with Bone Metastases Starting Zometa Treatment.

URCC-0701

Effects of Exercise on Cancer-Related Fatigue.

URCC-10055

Assessment Of Cognitive Function In Breast Cancer And Lymphoma Patients Receiving Chemotherapy At Pre-Treatment, Post-Treatment And At Six Month Follow-Up

Information and Referral Form

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BRAIN

TREATMENT:

N0872

Study of Either Dasatinib or Placebo Combined with Bevacizumab in Recurrent Glioblastoma

N0877

Trial of Either Dasatinib or Placebo Combined With Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme (GBM)

Brain Cancer Contol:

A221101

Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients with Glioblastoma Multiforme

 

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BREAST

BREAST CANCER CONTROL:

NSABP B-43

Herceptin Given Concurrently with Radiation Therapy vs Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

S0927

Trial of Omega-3-Fatty Acid for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain and Stiffness in Women with Early Stage Breast Cancer

S1105

Trial Of A Text-Messaging Intervention To Reduce Early Discontinuation Of Adjuvant Aromatase Inhibitor Therapy In Women With Early Stage Breast Cancer

WFU-97609

Impact of Genomics and Exposures on Disparities in Breast Cancer Radiosensitivity

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HER2+:

BO25126

A randomized multicenter, double-blind, placebo-controlled comparison of chemotherapy plus trastuzumab plus placebo versus chemotherapy plus trastuzumab plus pertuzumab as adjuvant therapy in patients with operable HER2-positive primary breast cancer

FB-7

A Phase II Randomized Clinical Trial Evaluating Neoadjuvant Therapy Regimens with Weekly Paclitaxel and Neratinib or Trastuzumab Followed by Doxorubicin and Cyclophosphamide with Postoperative Trastuzumab in Women with Locally Advanced HER2-Positive Breast Cancer

METASTATIC:

8129

IMC-A12 in Combination With Temsirolimus in Patients With Metastatic Breast Cancer

E2108

The Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer

E3108

Prospective Trial Correlating Progression Free Survival With CYP2D6 Activity in Patients With Metastatic Breast Cancer Treated With Single Agent Tamoxifen

Nodal:

NSABP B-47

Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer

NSABP B-49

Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node-Positive or High-Risk
Node-Negative, HER2-Negative Breast Cancer

NSABP B-51

Evauluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients With Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

S1007

Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less

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GASTROINTESTINAL:

COLORECTAL CANCER PREVENTION:

GLNE 010

Validation and Comparison of Biomarkers for the Early Detection of Colorectal Adenocarcinoma

NSABP P-5

Statin Polyp Prevention Trial in Patients with Resected Colon Cancer.

OCCPI

Ohio Colorectal Cancer Prevention Initiative: Universal Screening for Lynch Syndrome

S0820

Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers for Patients with Stage 0-III Colon Cancer, Phase III - Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES)

COLORECTAL TREATMENT:

CALGB-80702

6 versus 12 Treatments of Adjuvant FOLFOX Plus Celecoxib or Placebo for Patients With Resected Stage III Colon Cancer

ESOPHAGEAL:

RTOG-1010

Evaluating The Addition Of Trastuzumab To Trimodality Treatment Of Her2-Overexpressing Esophageal Adenocarcinoma

S1201

Evaluating Treatment for Patients Based on ERCC1 (Excision Repair Cross- Complementing 1) for Advanced/Metastatic Esophageal, Gastric or Gastroesophageal Junction (GEJ) Cancer

LIVER:

CALGB-80802

Nexavar Plus Adriamycin vs Nexavar in Patients with Advanced Hepatocellular Carcinoma.

PANCREATIC:

ACOSOG-Z5041

Preoperative Gemzar and Tarceva Plus Pancreatectomy and Postoperative Gemzar and Tarceva for Patients with Operable Pancreatic Adenocarcinoma.

S1115

Trial of AZD6244 Hydrogen Sulfate (NSC-748727) and MK-2206 (NSC-749607) vs mFOLFOX in Patients With Metastatic Pancreatic Cancer After Prior Chemotherapy

RECTAL:

N1048

Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision

S0713

Oxaliplatin, Xeloda, Erbitux and Radiation in Pre-operative Therapy of Rectal Cancer.

 

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GENITOURINARY:

PROSTATE:

RTOG-1115

Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer

S1014

Abiraterone Acetate Treatment for Prostate Cancer Patients with a PSA of More Than Four Following Initial Androgen Deprivation Therapy

S1216

Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer

RENAL:

E2810

Pazopanib vs. Placebo in Patients with Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy

S0931

EVEREST: EVErolimus for Renal Cancer Ensuing Surgical Therapy

S1107

Evaluation of ARQ 197 and ARQ 197 in Combination With Erlotinib in Papillary Renal Cell Carcinoma

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GYN:

GYN Cancer Control

GOG-0273

Chemotherapy toxicity in elderly women with ovarian, primary peritoneal or fallopian tube cancer

Cervical

RTOG-1203

Study Of Standard Vs. IMRT Pelvic Radiation For Post-Operative Treatment Of Endometrial And Cervical Cancer ( Time-C)

OVARIAN:

NCIC CTG OV.21

Intraperitoneal (IP) plus Intravenous (IV) Chemotherapy versus IV Carboplatin plus Paclitaxel in Patients with Epithelial Ovarian Cancer Optimally Debulked at Surgery following Neoadjuvant Intravenous Chemotherapy

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Head & Neck

RTOG-12616 Pending Approval

Randomized Phase Ii/Iii Trial Of Surgery And Postoperative Radiation Delivered With Concurrent Cisplatin Versus Docetaxel Versus Docetaxel And Cetuximab For High-Risk Squamous Cell Cancer Of The Head And Neck

 

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LEUKEMIA:

AML:

E2906

Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age ≥ 60 Years)

S1203

Study of Standard Cytarabine Plus Daunorubicin (7+3) Therapy or Idarubicin With High Dose Cytarabine (IA) Versus IA With Vorinostat (IA+V) in Younger Patients With Previously Untreated Acute Myeloid Leukemia (AML)


LEUKEMIA OTHER:

551-1019

Open-label Study of MEDI-551 and Bendamustine vs Rituximab and Bendamustine in Adults With Relapsed or Refractory CLL

E1908

Standard and Low Dose Rituximab: Initial Treatment of Progressive Chronic Lymphocytic Leukemia in Elderly Patients Using Alemtuzumab and Rituximab.

LUNG:


NSCLC:

CALGB-30801

Trial Evaluating Selective Cox-2 Inhibition In Cox-2 Expressing Advanded Non-Small Cell Lung Cancer.

E1505

Adjuvant Chemotherapy with or without Avastin for Patients with Completely Resected Stage IB(>=4 cm)-IIIA Non-Small Cell Lung Cancer.

E5508

Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paxlitaxel and Bevacizumab for Advanced Non-Squamous NSCLC

MO22097

An Open-Label, Randomized, Phase IIIb Trial Evaluating the Efficacy and Safety of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression of Disease in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) after First-Line Treatment with Bevacizumab Plus a Platinum Doublet-Containing Chemotherapy

RC1126

Erlotinib Alone or in Combination with Bevacizumab in Patients with Non-Small Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations

S0819

Carboplatin/Taxol or Carboplatin/Taxol/Avastin with/without Concurrent Erbitux in Patients with Advanced Non-Small Cell Lung Cancer.

SCLC:

IPM3002
Palifosfamide-tris, A Novel DNA Crosslinker, in Combination with Carboplatin and Etoposide (PaCE) Chemotherapy versus Carboplatin and Etoposide (CE) Alone in Chemotherapy Naive Patients with Extensive-Stage Small Cell Lung Cancer.

Other:

S0905

Study of Cediranib (NSC#732208) versus Placebo in Combination With Cisplatin and Pemetrexed in Chemonaive Patients With Malignant Pleural Mesothelioma

LYMPHOMA:

HODGKIN'S:

E2410

Response-Adapted Therapy Based on Positron Emission Tomography (PET) for Bulky Stage I and II Classical Hodgkin Lymphoma (HL)

NON- HODGKIN

PIX306

Comparing Pixantrone + Rituximab with Gemcitabine + Rituximab in Patients with Aggressive B-cell Non-Hodgkin Lymphoma Who Have Relapsed after Therapy with CHOP-R or an Equivalent Regimen and are Ineligible for Stem Cell Transplant

Lymphoma/Other

551-1088 (Temporarily Closed to accrual)

Randomized Open-label Study of MEDI-551 in Adults With Relapsed or Refractory DLBCL

CALGB-50904

Ofatumumab and Bendamustine vs. Ofatumumab, Bortezomib and Bendamustine in Patients with Untreated Follicular Lymphoma

E1411

Four Arm Study In Patients ≥ 60 With Previously Untreated Mantle Cell Lymphoma Of Therapy With: Arm A = Rituximab+ Bendamustine Followed By Rituximab Consolidation (RB → R); Arm B = Rituximab + Bendamustine + Bortezomib Followed By Rituximab Consolidation (RBV→ R), Arm C = Rituximab + Bendamustine Followed By Lenalidomide + Rituximab Consolidation (RB → LR) or Arm D = Rituximab + Bendamustine + Bortezomib Followed By Lenalidomide + Rituximab Consolidation (RBV → LR)

S0806

Vorinostat (SAHA) (NSC-701852) in Combination With Rituximab-CHOP in Patients With Newly Diagnosed Advanced Stage Diffuse Large B-Cell Lymphoma (DLBCL)

S1001

PET-Directed Therapy for Limited Stage Diffuse Large B-cell Lymphoma (DLBCL)

S1106

Trial of R-HCVAD/MTX/Ara-C Induction Followed by Consolidation With an Autologous Stem Cell Transplant vs. R-Bendamustine Induction Followed by Consolidation With an Autologous Stem Cell Transplant for Patients ≤ 65 Years of Age With Previously Untreated Mantle Cell Lymphoma

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MELANOMA:

E1609

A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon α-2b for Resected High-Risk Melanoma

N0879

Carbo/Taxol/Avastin +/- Afinitor for Therapy of Metastatic Malignant Melanoma.

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MYELOMA:

 

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SARCOMA:

A091102

Study of MLN8237 in Advanced/ Metastatic Sarcoma

A091103

Angiopoietin-1 and -2 peptibody amg 386 for the treatment of Angiosarcoma

OTHER:

A091104

Study of MK-2206 in patients with progressive, recurrent/metastatic adenoid cystic carcinoma

N0392

Assessment of Patient Satisfaction with Participation on Phase II/III NCCTG Clinical Trials.

 

QUESTIONS?

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OR ASK YOUR PHYSICIAN
"Is There a Clinical Trial For Me?"

Contact Us

By Phone:
(937) 775-1350
Fax:
(937) 775-1358
By Mail:
Dayton Clinical Oncology Program
3123 Research Blvd., Suite 150
Dayton, Ohio 45420