Department of Biochemistry & Molecular Biology

Michael Leffak, Ph.D., Interim Chair

Dr. S. Dean Rider Jr.

Stanley Dean Rider Jr., Ph.D.
Research Assistant Professor

Office: 112 Diggs Lab
Lab: 064 Diggs Lab
(937) 775-3249
E-mail: Dr. Rider

Education

Ph.D.: 2000 Purdue University (J. J. Stuart)
Postdoctoral: Purdue University (J. P. Ogas)
Postdoctoral: Texas A&M University (G. Zhu)

Research Interests

My research is focused on chromatin remodeling and regulation of gene expression in eukaryotes. My time is currently divided among three major areas, including 1) DNA sequencing and Genotyping for members of the Wright State community through the Center for Genomics Research; 2) Identification of small molecule inhibitors for an unusual type of histone deacetylase from pathogenic microbes (malaria, toxoplasmosis, and cryptosporidiosis), and 3) in collaboration with Dr. Hostetler, understanding nuclear hormone receptors that respond to nutrients to alter gene expression

Selected References

Rider, Jr., S.D., D. G. Srinivasan, and R.S. Hilgarth. 2010 Chromatin-Remodelling Proteins of the Pea Aphid, Acyrthosiphon pisum (Harris). Insect Molecular Biology, S2: 201-214.

International Aphid Genomics Consortium (includes S. D. Rider, Jr.). 2010. Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biology. 8: e1000313.

Ramsey, J.S., Rider, D.S., Walsh, T.K., De Vos, M., Gordon, K.H.J., Ponnala, S.L., Macmil, S., Roe, B.A., and Jander, G. 2010. Comparative analysis of detoxification enzymes in Acrythosiphon pisum and Myzus persicae. Insect Molecular Biology S2: 155-164.

Rider, Jr., S. D., and G. Zhu. 2010. Cryptosporidium: Genomic and Biochemical Features. Exp. Parasitol. 124: 2-9.

Rider, Jr., S. D., and G. Zhu. 2009. An Apicomplexan Ankyrin Repeat Histone Deacetylase with Relatives in Photosynthetic Eukaryotes. Int. J. Parasitol, 39: 747-754. [COVER ARTICLE]

Muir, W. M., Rosa, G. J. M., Pittendrigh, B. R., Xu, S., Rider, S. D., Fountain, M., and Ogas, J. 2009. A mixture model approach for the analysis of small exploratory microarray experiments. Computational Statistics and Data Analysis, 53: 1566-1576.

Rider, Jr. S. D., and G. Zhu. 2008. Differential Expression of the two distinct Replication Protein A subunits from Cryptosporidium parvum. J. Cell. Biochem 104: 2207-2216.

Zhang, H., Rider, Jr., S. D., Henderson, J. T., Fountain, M., Chuang, K., Kandachar, V., Simons, A., Jerome, R. J., Edenberg, H. J., Romero-Severson, J., Muir, W. M., and Ogas, J. P. 2008. The CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27. J. Biol. Chem. 283: 22637-22648.

Rider, Jr. S. D., and G. Zhu. "Apicomplexans - Cryptosporidium spp." In Emerging Protozoan Pathogens. Ed. N. A. Khan. Oxford: Taylor & Francis, 2007. 193-225.

Muir, W. M., Romero-Severson, J., Rider, Jr., S. D., Simons, A., Ogas, J., 2006. Application of one-sided t-tests and a generalized experiment wise error rate to high-density oligonucleotide microarray experiments: An example using Arabidopsis. J. Data Sci. 4: 323-341.

Li, H.-C., Chuang, K., Henderson, J. T., Rider, Jr., S. D., Bai, Y., Zhang, H., Fountain, M., Gerber, J., and Ogas, J. 2005. PICKLE acts during germination to repress expression of embryonic traits. Plant J. 44(6):1010-1022.

Rider, Jr., S. D., Cai, X-M., Sullivan, Jr., W. J., Smith, A. T., Radke, J., White, M. and Zhu, G., 2005. The Protozoan Parasite Cryptosporidium parvum Possesses Two Functionally and Evolutionarily Divergent Replication Protein A Large Subunits. J. Biol. Chem. 280(36):31460-31469.