Madhavi P. Kadakia, Ph.D.
Associate Director, Center for Genomics Research
Office: 122 Diggs Lab
Lab: 125 Diggs Lab
Graduate School of Public Health, University of Pittsburgh (Infectious Diseases and Microbiology)
Doctorate 1995 (University of Pittsburgh)
Post-doctorate (University of Pittsburgh)
Mutations in p63, a p53 related protein, are rare in human cancers but have been shown to be prevalent in patients with ectrodactyly, ectodermal dysplasia and cleft lip/palate (EEC) syndrome and split hand-split foot malformations (SHFM). The goal of our laboratory is to identify genes that are regulated by p63 that will provide new insights into the function of p63 and its potential role in both development and cancer. Two projects in the lab focuses on studying the regulation of Vitamin D Receptor and Sonic Hedgehog signaling pathways, both of which play an important role in both development and cancer, by p63. A third project involves studying the effects of mutant forms of p63 on biological activity of p53 and p63.
In addition to the projects on p63, our laboratory through our collaboration with Air Force Research Laboratory, is involved in two DoD-funded projects. The first project involves studying the effects of patterned silk film cast from ionic liquids as scaffolds for cell growth and differentiation. The other project involves use of hybrid nanostructures for studying signal transduction and creating molecular scale diagnostic or sensing devices.
Gupta MK, Khokhar SK, Phillips DM, Sowards LA, Drummy LF, Kadakia MP, Naik RR Patterned Silk Films Cast from Ionic Liquid Solubilized Fibroin as Scaffolds for Cell Growth Langmuir (In press)
Caserta TM, Kommagani R, Yuan Z, Robbins DJ, Mercer CA, Kadakia MP. p63 overexpression induces the expression of Sonic Hedgehog. (2006) Mol Cancer Res. Oct;4(10):759-68.
Heminger K, Jain V, Kadakia MP, Dwarakanath B, Berberich SJ. Altered Gene Expression Induced by Ionizing Radiation and Glycolytic Inhibitor 2-Deoxy-Glucose in a Human Glioma Cell Line: Implications for Radio Sensitization. (2006) Cancer Biol Ther. 11;5(7)
Kommagani R, Caserta TM, Kadakia MP. Identification of vitamin D receptor as a target of p63. (2006) Oncogene. 22;25(26):3745-51.
Rozenzhak SM, Kadakia MP, Caserta TM, Westbrook TR, Stone MO, Naik RR. Cellular internalization and targeting of semiconductor quantum dots. (2005) Chem Commun. 7;(17):2217-9.
MP Kadakia, T. L. Brown, M. McGorry, and Berberich S.J. (2002) MdmX inhibits Smad transactivation. Oncogene. 21(57):8776-85.
MP Kadakia, C. Slader, & S. J. Berberich. (2000) Regulation of p63 function of Mdm2 and MdmX. DNA Cell Biol. 20(6):321-330
J. Goydos & MP Kadakia (1999). The Clinical Relevance of the Fas-FasL Interaction. Cancer Therapeutics 2:107-112.
J. Goydos, MP. Kadakia, M. V. Tirabassi, D. Perez, & E. White. (1999). Rendering Cells Resistant to Fas Ligand-Induced Apoptosis. Surgical Forum. 50: 341-342
J. Goydos, , MP. Kadakia, M. V. Tirabassi, M. Doshi, D. Perez, & E. White. (1999). Rendering Immune Effector Cells Resistant to Fas Ligand-Induced Apoptosis. J. Surg. Res. 86:275
MP. Kadakia (1998). Human Herpesvirus 6 Infection and Associated Pathogenesis Following Bone Marrow Transplantation. Leukemia and Lymphoma 31: 251-266.
M. Kadakia, W. B. Rybka, J. A. Stewart, J. L. Patton, F. R. Stamey, M. Elsawy, P. E. Pellett, & J. A. Armstrong (1996). Human Herpesvirus 6: Infection and Disease Following Autologous and Allogeneic Bone Marrow Transplantation. Blood 87: 5341-5354.